Cognitive Performance Is Highly Stable over a 2-Year-Follow-Up in Chronic Kidney Disease Patients in a Dedicated Medical EnvironmentReport as inadecuate




Cognitive Performance Is Highly Stable over a 2-Year-Follow-Up in Chronic Kidney Disease Patients in a Dedicated Medical Environment - Download this document for free, or read online. Document in PDF available to download.

Background

As kidney and brain functions decline with aging, chronic kidney disease CKD and dementia are becoming increasing health burdens worldwide. Among the risk factors for cognitive impairment, CKD is increasingly recognized. The precise impact of CKD on the development of cognitive impairment is poorly understood.

Methods

In the New Tools for the Prevention of Cardiovascular Disease in Chronic Kidney Disease NTCVD cohort, which was recruited in a dedicated nephrology department, we examined the 2-year course of cognitive performance in 120 patients 73 patients with CKD stages 3–5D, 47 control patients without CKD with similar vascular risk profile using a comprehensive battery of 10 neuropsychological tests.

Results

Kidney function, vascular risk factors and cognitive performance were highly stable both in CKD and control patients. The summary score of cognitive performance in CKD patients was very similar at baseline z = -0.63±0.76 and follow-up z = -0.54±0.79, p = 0.113, as was cognitive performance in control patients z = -0.01±0.59 and 0.01±0.70, p = 0.862, at baseline and follow-up, respectively. Total serum cholesterol 199.6±36.0 and 186.0±32.9, p = 0.005 in controls; 194.4±46.1 and 181.2±41.2, p = 0.008 in CKD and common carotid intima-media thickness 0.87±0.18 and 0.84±0.17, p = 0.351 in controls; 0.88±0.21 and 0.82±0.16, p = 0.002 in CKD moderately but significantly decreased during the follow-up. In multivariable regression analyses, high age β = -0.28, 95%CI = -0.48 to 0.08, p = 0.007 predicted decrease in cognitive performance.

Conclusions

In this well-defined cohort receiving state-of-the-art therapy, cognitive performance did not decrease over 2 years. Our data emphasize the aspect of risk factor control, suggesting that dedicated medical care might prevent cognitive decline in CKD patients.



Author: Janine Gronewold, Olga Todica, Ulla K. Seidel, Michaela Volsek, Andreas Kribben, Heike Bruck, Dirk M. Hermann

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents