Circulating Angiopoietin-2 and Its Soluble Receptor Tie-2 Concentrations Are Related to Renal Function in Two Population-Based CohortsReport as inadecuate




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Background

An intact angiopoietin-Tie-2 ligand receptor system is indispensable for life. High circulating angiopoietin-2 Ang-2 concentrations are strongly associated with kidney disease involving the progressive loss of glomerular filtration. The aim of our study was to investigate the associations between renal function and serum Ang-2 or serum Tie-2 concentrations in the general population.

Methods

Data of 3081 and 4088 subjects from two population-based studies, the Study of Health in Pomerania SHIP-1 and SHIP-Trend, were used. Renal function was assessed by serum creatinine, cystatin C concentration, creatinine-based estimated glomerular filtration rate eGFRcrea, cystatin C-based eGFR eGFRcys and urinary albumin-to-creatinine ratio uACR. Analyses of variance and linear regression models were calculated.

Results

In both cohorts, strong positive associations between serum cystatin C concentrations and serum Ang-2 or Tie-2 concentrations as well as inverse associations between eGFRcys and serum Ang-2 or Tie-2 concentrations were found. These relations were also present in a subpopulation without hypertension or diabetes mellitus type 2. Furthermore, we detected weak U-shaped associations between serum creatinine concentrations or eGFRcrea and serum Ang-2 concentrations. With respect to uACR a strong positive association with serum Ang-2 concentrations was revealed.

Conclusion

Serum Ang-2 concentrations are strongly associated with sensitive parameters of renal impairment like serum cystatin C, uACR and eGFRcys. These findings persisted even after exclusion of subjects with hypertension or diabetes mellitus type 2, conditions that predispose to chronic renal disease and are associated with increased Ang-2 concentrations. Interestingly, we did not detect the same strong relations between serum creatinine and eGFRcrea with serum Ang-2 concentration. Additionally, significant association of serum Tie-2 concentrations with cystatin C and eGFRcys were detected.



Author: Anna Hennings, Anke Hannemann, Rainer Rettig, Marcus Dörr, Matthias Nauck, Henry Völzke, Markus M. Lerch, Wolfgang Lieb, Nele F

Source: http://plos.srce.hr/



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