Involvement of Activating NK Cell Receptors and Their Modulation in Pathogen ImmunityReport as inadecuate




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Journal of Biomedicine and BiotechnologyVolume 2011 2011, Article ID 152430, 11 pages

Review Article

Centro di Eccellenza per la Ricerca Biomedica CEBR, Università di Genova, 16132 Genova, Italy

Istituto G. Gaslini, 16147 Genova, Italy

Department of Health Sciences DISSAL, University of Genova, 13132 Genova, Italy

Infectious Diseases Unit, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, 16132 Genova, Italy

Received 6 April 2011; Accepted 23 May 2011

Academic Editor: Lorenzo Moretta

Copyright © 2011 Francesco Marras et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Natural Killer NK cells are endowed with cell-structure-sensing receptors providing inhibitory protection from self-destruction inhibitory NK receptors, iNKRs, including killer inhibitory receptors and other molecules and rapid triggering potential leading to functional cell activation by Toll-like receptors TLRs, cytokine receptors, and activating NK cell receptors including natural cytotoxicity receptors NCRs, i.e., NKp46, NKp46, and NKp44. NCR and NKG2D recognize ligands on infected cells which may be endogenous or may directly bind to some structures derived from invading pathogens. In this paper, we address the known direct or indirect interactions between activating receptors and pathogens and their expression during chronic HIV and HCV infections.





Author: Francesco Marras, Federica Bozzano, and Andrea De Maria

Source: https://www.hindawi.com/



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