Does Total Gastrectomy Provide Better Outcomes than Distal Subtotal Gastrectomy for Distal Gastric Cancer A Systematic Review and Meta-AnalysisReport as inadecuate




Does Total Gastrectomy Provide Better Outcomes than Distal Subtotal Gastrectomy for Distal Gastric Cancer A Systematic Review and Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

Background-Aims

Total gastrectomy TG has shown to be superior regarding low risk of recurrence and readmission to distal subtotal gastrectomy DG for treatment of distal stomach cancer, but the incidence of postoperative morbidity and mortality in TG cannot be ignored. Therefore, we performed a meta-analysis to compare the effectiveness between TG and DG for distal stomach cancer.

Methodology

A search in PubMed, EMBASE, the Cochrane Library, Web of Science, Chinese Biomedical Database through January 2016 was performed. Eligible studies in comparing of TG and DG for distal gastric cancer were included in this meta-analysis. Review Manager 5.2 software from the Cochrane Collaboration was used for the performance of meta-analysis and STATA 12.0 software for meta-regression analysis.

Results

Ten retrospective cohort studies and one randomized control trial involving 5447 patients were included. The meta-analysis showed no significant difference of postoperative mortality RR = 1.48, 95%CI = 0. 90–2.44,p = 0.12, intraoperative blood loss MD = 24.34, 95%CI = -3.31–51.99, p = 0.08 and length of hospital stayMD = 0.76, 95%CI:-0.26–1.79, p = 0.15. TG procedure could retrieve more lymph nodes than DGMD = 4.33, 95% CI = 2.34–6.31, p<0.0001. According to different postoperative complications, we performed subgroup analysis, subgroup analysis revealed that patients in TG group tended to have a higher rate of postoperative intra-abdominal abscess than DG procedure RR = 3.41, 95% CI = 1.21–9.63,p<0.05. No statistical differences were found in leakage, intestinal obstruction, postoperative bleeding, anastomotic stricture and wound infection between the two groups p>0.05. We pooled the data together, the accumulated 5-year Overall Survival rates of TG and DG groups were 49.6% 919-1852 vs.55.9%721-1290 respectively. Meta-analysis revealed a favoring trend to DG procedure and there was a statistical difference between the two groups RR = 0.91,95% CI = 0.85–0.97,p = 0.006.

Conclusion

Based on current retrospective evidences, we found that in spite of similar postoperative mortality, TG for distal gastric cancer provided a high risk of five-year Overall Survival rate. DG procedure can be a recommendation for distal gastric cancer, whereas due to lack of high quality RCTs in multicenter and the relatively small sample size of long-term outcomes, further comparative studies are still needed.



Author: Jin Qi, Peng Zhang, Yanan Wang, Hao Chen, Yumin Li

Source: http://plos.srce.hr/



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