Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly methyl methacrylate-Nylon6 Core-Shell NanofibersReport as inadecuate




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Antibacteria activity, Drug release, Electrospinning, Core-shell fibers, Kinetics of drug release, Drug delivery

Sohrabi, Amirreza

Supervisor and department: Thundat, Thomas Department of Chemical and Materials Engineering

Examining committee member and department: Thundat, Thomas Department of Chemical and Materials Engineering Narain, Ravin Department of Chemical and Materials Engineering Kaur, Kamiljit Department of Pharmacy and Pharmaceutical Science

Department: Department of Chemical and Materials Engineering

Specialization: Materials Engineering

Date accepted: 2012-09-17T09:39:02Z

Graduation date: 2012-09

Degree: Master of Science

Degree level: Master's

Abstract: A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly methyl methacrylatePMMA-Nylon6 core-shell nanofibers and the release characteristics and antibacterial activity of the system were investigated. It was revealed that the system is capable of releasing the drug with a sustained manner through a three stages release in which the release in stage I followed the non-Fickian diffusion; however, Fickian diffusion was proven to be the release mechanism of stages II and III. The diffusion coefficient calculations indicated a significant decrease in the coefficient from stage II to stage III which is believed to be the consequent of fibers crystallization as a result of the long-term incubation in an aqueous solution. Finally, the antibacterial activity of the system was verified by means of optical density OD measurements against gram positive L.innocua.

Language: English

DOI: doi:10.7939-R3XH6P

Rights: Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.





Author: Sohrabi, Amirreza

Source: https://era.library.ualberta.ca/


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University of Alberta Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core-Shell Nanofibers by Amirreza Sohrabi A thesis is submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science In Materials Engineering Department of the Chemical and Materials Engineering ©Amirreza Sohrabi Fall 2012 Edmonton, Alberta Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only.
Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the authors prior written permission. Dedication I would like to dedicate this thesis to my great family whose support and encouragement has always enlightened my life and my wife whose helps made this study possible. Abstract A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly (methyl methacrylate)(PMMA)-Nylon6 core-shell nanofibers and the release characteristics and antibacterial activity of the system were investigated.
It was revealed that the system is capable of releasing the drug with a sustained manner through a three stages release in which the release in stage I followed the non-Fickian diffusion; however, Fickian diffusion was proven to be the release mechanism of stages II and III.
The diffusion coefficient calculations indicated a significant decrease in the coefficient from stage II to stage III which is believed to be th...





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