A Simpler Creatinine Index Can Predict Long-Term Survival in Chinese Hemodialysis PatientsReport as inadecuate




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Background

Low lean body mass LBM is an indicator of malnutrition inflammation syndrome, which is common in hemodialysis HD patients. The creatinine index CI has been validated as a reliable method to estimate LBM and evaluate the protein-energy status of HD patients. However, the traditional creatinine index formula was complex. We sought to investigate the impact of CI derived from a new simple formula on Chinese HD patient outcomes.

Methods

In this retrospective cohort study, we enrolled 1269 patients who initiated HD between February 1981 and February 2012 and followed them until the end of February 2013. CI was calculated using the simple creatinine kinetic model CKM formula. Multiple linear regression analysis and Cox regression proportional hazard analysis were used to define independent variables and compare survival between groups.

Results

The 1269 HD patients were categorized into 3 groups according to the tertiles of calculated CI between men and women. Each group consisted of 423 patients 50.6% men, 49.4% women. Patients in the highest sex-specific tertile of CI had longer overall survival HR, 0.46; P 0.002. BMI did not significantly associate with survival after adjustment HR,0.99; P 0.613.

Conclusions

CI derived from the simple CKM formula serves as a good parameter than BMI to predict the survival of HD patients. The formula could extend its convenient use in clinical practice for HD patients.



Author: Chiung-Ying Huang, Szu-Ying Lee, Chung-Wei Yang, Szu-Chun Hung, Chih-Kang Chiang, Jenq-Wen Huang , Kuan-Yu Hung

Source: http://plos.srce.hr/



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