Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT ConsortiumReport as inadecuate




Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium - Download this document for free, or read online. Document in PDF available to download.

Meta-analysis of single trait for multiple cohorts has been used for increasing statistical power in genome-wide association studies GWASs. Although hundreds of variants have been identified by GWAS, these variants only explain a small fraction of phenotypic variation. Cross-phenotype association analysis CPASSOC can further improve statistical power by searching for variants that contribute to multiple traits, which is often relevant to pleiotropy. In this study, we performed CPASSOC analysis on the summary statistics from the Genetic Investigation of ANthropometric Traits GIANT consortium using a novel method recently developed by our group. Sex-specific meta-analysis data for height, body mass index BMI, and waist-to-hip ratio adjusted for BMI WHRadjBMI from discovery phase of the GIANT consortium study were combined using CPASSOC for each trait as well as 3 traits together. The conventional meta-analysis results from the discovery phase data of GIANT consortium studies were used to compare with that from CPASSOC analysis. The CPASSOC analysis was able to identify 17 loci associated with anthropometric traits that were missed by conventional meta-analysis. Among these loci, 16 have been reported in literature by including additional samples and 1 is novel. We also demonstrated that CPASSOC is able to detect pleiotropic effects when analyzing multiple traits.



Author: Haeil Park , Xiaoyin Li , Yeunjoo E. Song, Karen Y. He, Xiaofeng Zhu

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents