A Novel Inflammation- and Nutrition-Based Prognostic System for Patients with Laryngeal Squamous Cell Carcinoma: Combination of Red Blood Cell Distribution Width and Body Mass Index COR-BMIReport as inadecuate




A Novel Inflammation- and Nutrition-Based Prognostic System for Patients with Laryngeal Squamous Cell Carcinoma: Combination of Red Blood Cell Distribution Width and Body Mass Index COR-BMI - Download this document for free, or read online. Document in PDF available to download.

Background

Laryngeal squamous cell carcinoma LSCC is a head and neck cancer type. In this study, we introduced a novel inflammation- and nutrition-based prognostic system, referred to as COR-BMI Combination of red blood cell distribution width and body mass index, for LSCC patients.

Methods

A total of 807 LSCC patients 784 male and 23 female, 22–87 y of age who underwent surgery were enrolled in this retrospective cohort study. The patients were stratified by COR-BMI into three groups: COR-BMI 0 RDW ≤ 13.1 and BMI ≥ 25; COR-BMI 1 RDW ≤ 13.1 and BMI < 18.5 or 18.5 ≤ BMI < 25; RDW > 13.1 and 18.5 ≤ BMI < 25 or BMI ≥ 25; or COR-BMI 2 RDW > 13.1 and BMI < 18.5. Cox regression models were used to investigate the association between COR-BMI and cancer-specific survival CSS rate among LSCC patients.

Results

The 5-y, 10-y, and 15-y CSS rates were 71.6%, 60.1%, and 55.4%, respectively. There were significant differences among the COR-BMI groups in age < 60 versus ≥ 60 y; P = 0.005 and T stage T1, T2, T3, or T4; P = 0.013. Based on the results, COR-BMI 1 versus 0: HR = 1.76; 95% CI = 0.98–3.15; 2 versus 0: HR = 2.91; 95% CI = 1.53–5.54, P = 0.001 was a significant independent predictor of CSS.

Conclusion

COR-BMI is a novel inflammation- and nutrition-based prognostic system, which could predict long-term survival in LSCC patients who underwent surgery.



Author: Yan Fu , Yize Mao , Shiqi Chen, Ankui Yang, Quan Zhang

Source: http://plos.srce.hr/



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