Mechanism of Oxidation of L-Histidine by Heptavalent Manganese in Alkaline MediumReport as inadecuate

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E-Journal of Chemistry - Volume 2 2005, Issue 1, Pages 75-85

Department of Chemistry, Karnatak Science College, Dharwad-580001, India

Postgraduate Department of Studies in Chemistry, Karnatak University, Dharwad-580003, India

Received 6 November 2004; Accepted 14 December 2004

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The kinetics of oxidation of L-histidine by manganeseVII in aqueous alkaline medium at a constant ionic strength of 0.05 mol dm

was studied spectrophotometrically. The reaction between permanganate and L-histidine in alkaline medium exhibits 2:1 stoichiometry KMnO4: L-histidine. The reaction is of first order in KMnO4, less than unit order in L-histidine and alkali. Decrease in the dielectric constant of the medium decreases the rate of reaction. Effect of added products and ionic strength of the reaction medium have been investigated. The main products were identified by spot test and I.R. A mechanism involving the free radical has been proposed. In composite equilibrium step L-histidine binds to MnO4

species to form a complexC. The reaction constants involved in the different steps of mechanism are evaluated. The activation parameters with respect to slow step of the mechanism are computed and discussed and thermodynamic quantities are also determined.

Author: Timy P. Jose, Sharanappa T. Nandibewoor, and Suresh M. Tuwar



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