Nasopharyngeal Pneumococcal Carriage among Healthy Children in Cyprus Post Widespread Simultaneous Implementation of PCV10 and PCV13 VaccinesReport as inadecuate




Nasopharyngeal Pneumococcal Carriage among Healthy Children in Cyprus Post Widespread Simultaneous Implementation of PCV10 and PCV13 Vaccines - Download this document for free, or read online. Document in PDF available to download.

The objective of the study was to describe the incidence of pneumococcal nasopharyngeal carriage, serotype distribution and antibiotic resistance profile of pneumococcal nasopharyngeal isolates in healthy children aged 6 to 36 months following the implementation of conjugate vaccines. A nasopharyngeal swab was collected from 1105 healthy children following a stratified random sampling between September 2013 and April 2014. Demographics, vaccination status and data on possible risk factors were recorded. Isolates were serotyped and tested for antibiotic susceptibility. The nasopharyngeal carriage rate was 25.3%. Among 1105 children enrolled, 393 had received PCV13 and 685 PCV10. The prevailing isolated serotypes were: 23A 14.3%, 15A 8.9%, 6C 8.6%, 23B 7.5%, 19A 5.4% and 15B 5%. The proportion of non-vaccine serotypes, PCV10 serotypes, PCV13 additional serotypes 3, 6A, 19A was 76.8%, 2.1% and 10.4% respectively. Although children, who were fully or partially vaccinated with PCV13, were 63% less likely to be colonized with additional PCV13 serotypes compared to those vaccinated with PCV10, the difference is not significant 95%Cl = 0.14–1.02, p = 0.053. The highest antibiotic non-susceptible rates were found for erythromycin 28.2% and penicillin 27.9%. The overall multidrug resistance rate was 13.2%, with serotypes 24F 4-6, 15A 14-25 and 19A 6-15 being the main contributors. Carriage rate was similar between children vaccinated with PCV10 or PCV13. The high incidence of 15A serotype which is also multidrug resistant should be underlined. Ongoing surveillance is needed to monitor the dynamics on nasopharyngeal carriage.



Author: Adamos Hadjipanayis , Elisavet Efstathiou, Maria Alexandrou, Loukia Panayiotou, Chrystalla Zachariadou, Panayiotis Petrou, Vasili

Source: http://plos.srce.hr/



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