Retinal Capillary Rarefaction in Patients with Type 2 Diabetes MellitusReport as inadecuate




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Purpose

In diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease.

Methods

This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance ICD and capillary area CapA, measured non-invasively and in vivo by scanning laser Doppler flowmetry, in 73 patients with type 2 diabetes, 55 healthy controls and 134 individuals with hypertension stage 1 or 2.

Results

In diabetic patients, ICD was greater 23.2±5.5 vs 20.2±4.2, p = 0.013 and CapA smaller 1592±595 vs 1821±652, p = 0.019 than in healthy controls after adjustment for differences in cardiovascular risk factors between the groups. Compared to hypertensive patients, diabetic individuals showed no difference in ICD 23.1±5.8, p = 0.781 and CapA 1556±649, p = 0.768.

Conclusion

In the early stage of diabetes type 2, patients showed capillary rarefaction compared to healthy individuals.



Author: Agnes Jumar, Joanna M. Harazny, Christian Ott, Stefanie Friedrich, Iris Kistner, Kristina Striepe, Roland E. Schmieder

Source: http://plos.srce.hr/



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