Clinical Features of Idiopathic Interstitial Pneumonia with Systemic Sclerosis-Related Autoantibody in Comparison with Interstitial Pneumonia with Systemic SclerosisReport as inadecuate




Clinical Features of Idiopathic Interstitial Pneumonia with Systemic Sclerosis-Related Autoantibody in Comparison with Interstitial Pneumonia with Systemic Sclerosis - Download this document for free, or read online. Document in PDF available to download.

Background

Patients with idiopathic interstitial pneumonias sometimes have a few features of connective tissue disease CTD and yet do not fulfil the diagnostic criteria for any specific CTD.

Objective

This study was conducted to elucidate the characteristics, prognosis, and disease behavior in patients with interstitial lung disease ILD associated with systemic sclerosis SSc-related autoantibodies.

Methods

We retrospectively analyzed medical records of 72 ILD patients: 40 patients with SSc SSc-ILD and 32 patients with SSc-related autoantibody-positive ILD but not with CTD ScAb-ILD, indicating lung-dominant CTD with SSc-related autoantibody.

Results

Patients with SSc-ILD were predominantly females and non-smokers, and most had nonspecific interstitial pneumonia confirmed by high-resolution computed tomography HRCT and pathological analysis. However, about half of the patients with ScAb-ILD were male and current or ex-smokers. On HRCT analysis, honeycombing was more predominant in patients with ScAb-ILD than with SSc-ILD. Pathological analysis showed the severity of vascular intimal or medial thickening in the SSc-ILD patients to be significantly higher than that in the ScAb-ILD patients. Survival curves showed that the patients with ScAb-ILD had a significantly poorer outcome than those with SSc-ILD.

Conclusion

Data from this study suggest that lung-dominant CTD with SSc-related autoantibody is a different disease entity from SSc-ILD.



Author: Hideaki Yamakawa , Eri Hagiwara, Hideya Kitamura, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Shinichiro Iso, K

Source: http://plos.srce.hr/



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