Cost-Effectiveness Analysis of 1-Year Treatment with Golimumab-Standard Care and Standard Care Alone for Ulcerative Colitis in PolandReport as inadecuate




Cost-Effectiveness Analysis of 1-Year Treatment with Golimumab-Standard Care and Standard Care Alone for Ulcerative Colitis in Poland - Download this document for free, or read online. Document in PDF available to download.

Objective

The objective of this study was to assess the cost-effectiveness of induction and maintenance treatment up to 1 year of ulcerative colitis with golimumab-standard care and standard care alone in Poland.

Methods

A Markov model was used to estimate the expected costs and effects of golimumab-standard care and a standard care alone. For each treatment option the costs and quality adjusted life years were calculated to estimate the incremental cost-utility ratio. The analysis was performed from the perspective of the Polish public payer and society over a 30-years time horizon. The clinical parameters were derived mainly from the PURSUIT-SC and PURSUIT-M clinical trials. Different direct and indirect costs and utility values were assigned to the various model health states.

Results

The treatment of ulcerative colitis patients with golimumab-standard care instead of a standard care alone resulted in 0.122 additional years of life with full health. The treatment with golimumab-standard care was found to be more expensive than treatment with the standard care alone from the public payer perspective and from social perspective. The incremental cost-utility ratio of golimumab-standard care compared to the standard care alone is estimated to be 391,252 PLN-QALY gained 93,155 €-QALYG from public payer perspective and 374,377 PLN-QALY gained 89,137 €-QALYG from social perspective.

Conclusions

The biologic treatment of ulcerative colitis patients with golimumab-standard care is more effective but also more costly compared with standard care alone.



Author: Ewa Stawowczyk, Paweł Kawalec , Andrzej Pilc

Source: http://plos.srce.hr/



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