Thermodynamics and Kinetics of a Go Proteinlike Heteropolymer Model with Two-State Folding Characteristics - Condensed Matter > Soft Condensed MatterReport as inadecuate




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Abstract: We present results of Monte Carlo computer simulations of a coarse-grainedhydrophobic-polar Go-like heteropolymer model and discuss thermodynamicproperties and kinetics of an exemplified heteropolymer, exhibiting two-statefolding behavior. It turns out that general, characteristic folding features ofrealistic proteins with a single free-energy barrier can also be observed inthis simplified model, where the folding transition is primarily driven by thehydrophobic force.



Author: Anna Kallias, Michael Bachmann, Wolfhard Janke

Source: https://arxiv.org/



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