Use of the Electronic Medical Record to Assess Pancreas Size in Type 1 DiabetesReport as inadecuate




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Aims

This study harnessed the electronic medical record to assess pancreas volume in patients with type 1 diabetes T1D and matched controls to determine whether pancreas volume is altered in T1D and identify covariates that influence pancreas volume.

Methods

This study included 25 patients with T1D and 25 age-, sex-, and weight-matched controls from the Vanderbilt University Medical Center enterprise data warehouse. Measurements of pancreas volume were made from medical imaging studies using magnetic resonance imaging MRI or computed tomography CT.

Results

Patients with T1D had a pancreas volume 47% smaller than matched controls 41.16 ml vs. 77.77 ml, P < 0.0001 as well as pancreas volume normalized by subject body weight, body mass index, or body surface area all P < 0.0001. Pancreatic volume was smaller with a longer duration of T1D across the patient population N = 25, P = 0.04. Additionally, four individual patients receiving multiple imaging scans displayed progressive declines in pancreas volume over time ~ 6% of volume-year, whereas five controls scanned a year apart did not exhibit a decline in pancreas size P = 0.03. The pancreas was uniformly smaller on the right and left side of the abdomen.

Conclusions

Pancreas volume declines with disease duration in patients with T1D, suggesting a protracted pathological process that may include the exocrine pancreas.



Author: John Virostko , Melissa Hilmes, Kelsey Eitel, Daniel J. Moore, Alvin C. Powers

Source: http://plos.srce.hr/



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