The Evonik-Mainz Eye Care-Study EMECS: Development of an Expert System for Glaucoma Risk Detection in a Working PopulationReport as inadecuate




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Purpose

To develop an expert system for glaucoma screening in a working population based on a human expert procedure using images of optic nerve head ONH, visual field frequency doubling technology, FDT and intraocular pressure IOP.

Methods

4167 of 13037 32% employees between 40 and 65 years of Evonik Industries were screened. An experienced glaucoma expert JW assessed papilla parameters and evaluated all individual screening results. His classification into -no glaucoma- -possible glaucoma- and -probable glaucoma- was defined as -gold standard-. A screening model was developed which was tested versus the gold-standard. This model took into account the assessment of the ONH. Values and relationships of CDR and IOP and the FDT were considered additionally and a glaucoma score was generated. The structure of the screening model was specified a priori whereas values of the parameters were chosen post-hoc to optimize sensitivity and specificity of the algorithm. Simple screening models based on IOP and - or FDT were investigated for comparison.

Results

111 persons 2.66% were classified as glaucoma suspects, thereof 13 0.31% as probable and 98 2.35% as possible glaucoma suspects by the expert. Re-evaluation by the screening model revealed a sensitivity of 83.8% and a specificity of 99.6% for all glaucoma suspects. The positive predictive value of the model was 80.2%, the negative predictive value 99.6%. Simple screening models showed insufficient diagnostic accuracy.

Conclusion

Adjustment of ONH and symmetry parameters with respect to excavation and IOP in an expert system produced sufficiently satisfying diagnostic accuracy. This screening model seems to be applicable in such a working population with relatively low age and low glaucoma prevalence. Different experts should validate the model in different populations.



Author: Jochen Wahl , Lorenz Barleon, Peter Morfeld, Andrea Lichtmeß, Sibylle Haas-Brähler, Norbert Pfeiffer

Source: http://plos.srce.hr/



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