A Systematic Literature Review and Meta-Regression Analysis on Early-Life Energy Restriction and Cancer Risk in HumansReport as inadecuate




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Background

In animal models, long-term moderate energy restriction ER is reported to decelerate carcinogenesis, whereas the effect of severe ER is inconsistent. The impact of early-life ER on cancer risk has never been reviewed systematically and quantitatively based on observational studies in humans.

Objective

We conducted a systematic review of observational studies and a meta-regression analysis on cohort studies to clarify the association between early-life ER and organ site-specific cancer risk.

Methods

PubMed and EMBASE 1982 –August 2015 were searched for observational studies. Summary relative risks RRs were estimated using a random effects model when available ≥3 studies.

Results

Twenty-four studies were included. Eleven publications, emanating from seven prospective cohort studies and some reporting on multiple cancer endpoints, met the inclusion criteria for quantitative analysis. Women exposed to early-life ER ranging from 220–1660 kcal-day had a higher breast cancer risk than those not exposed RRRE all ages = 1.28, 95% CI: 1.05–1.56; RRRE for 10–20 years of age = 1.21, 95% CI: 1.09–1.34. Men exposed to early-life ER ranging from 220–800kcal-day had a higher prostate cancer risk than those not exposed RRRE = 1.16, 95% CI: 1.03–1.30. Summary relative risks were not computed for colorectal cancer, because of heterogeneity, and for stomach-, pancreas-, ovarian-, and respiratory cancer because there were <3 available studies. Longer duration of exposure to ER, after adjustment for severity, was positively associated with overall cancer risk in women p = 0.02. Ecological studies suggest that less severe ER is generally associated with a reduced risk of cancer.

Conclusions

Early-life transient severe ER seems to be associated with increased cancer risk in the breast particularly ER exposure at adolescent age and prostate. The duration, rather than severity of exposure to ER, seems to positively influence relative risk estimates. This result should be interpreted with caution due to the limited number of studies and difficulty in disentangling duration, severity, and geographical setting of exposure.



Author: Rachel J. J. Elands , Colinda C. J. M. Simons, Martien van Dongen, Leo J. Schouten, Bas A. J. Verhage, Piet A. van den Brandt, Ma

Source: http://plos.srce.hr/



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