Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal CarcinomaReport as inadecuate




Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal Carcinoma - Download this document for free, or read online. Document in PDF available to download.

Purpose

We investigated if programmed death-ligand 1 PD-L1 expression levels were prognostic of survival outcomes after intensity-modulated radiation therapy IMRT for non-metastatic nasopharyngeal carcinoma NPC.

Methods and Materials

104 patients with non-metastatic NPC treated with radical IMRT were investigated for their PD-L1 expression by immunohistochemistry IHC which were correlated with survival endpoints including locoregional failure-free survival LRFFS, progression-free survival PFS, distant metastasis-free survival DMFS and overall survival OS.

Results

After a median follow-up of 7.6 years, 21 20.2%, 19 18.3% and 31 29.8% patients suffered from locoregional failure, distant metastases and overall disease progression, respectively, and 31 29.8% patients died. Patients whose tumors had PD-L1 IHC 2+ moderate to strong membrane staining in ≥ 25% of tumor cells enjoyed longer LRFFS 5-year 100% vs. 74.4%, Hazard ratio HR, 0.159, 95% confidence interval CI, 0.021–0.988; P = 0.042 and marginally longer PFS 5-year 95.0% vs. 65.2%, HR, 0.351, 95% CI, 0.08–0.999, P = 0.067 compared to those whose tumors had PD-L1 IHC 0 minimal membrane staining with PD-L1 in < 5% tumor cells or no staining with PD-L1 or 1+ minimal to moderate membrane staining with PD-L1 in between 5–24% tumor cells. PD-L1 IHC 2+ was independently prognostic of both LRFFS P = 0.014 and PFS P = 0.045 in multivariable analyses. Only induction chemotherapy followed by concurrent chemoradiation was prognostic of DMFS P = 0.003 and no prognostic factor for OS was identified.

Conclusion

PD-L1 expression levels correlated with LRRFS and PFS in non-metastatic NPC treated with radical IMRT. It may play a role in radiosensitivity for NPC, which should be further confirmed in prospective studies using immunotherapy together with IMRT.



Author: Victor H. F. Lee , Anthony W. I. Lo, Chun-Yin Leung, Wai-Hung Shek, Dora L. W. Kwong, Ka-On Lam, Chi-Chung Tong, Chun-Kin Sze, To

Source: http://plos.srce.hr/



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