Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer FunctionsReport as inadecuate




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Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies broader impact on understanding enhancer-promoter networks in regulation of gene expression.



Author: Yulia V. Skvortsova , Sofia A. Kondratieva , Marina V. Zinovyeva, Lev G. Nikolaev, Tatyana L. Azhikina, Ildar V. Gainetdinov

Source: http://plos.srce.hr/



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