Single-Nucleotide Polymorphisms and Markers of Oxidative Stress in Healthy WomenReport as inadecuate




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Purpose

There is accumulating evidence that oxidative stress is an important contributor to carcinogenesis. We hypothesized that genetic variation in genes involved in maintaining antioxidant-oxidant balance would be associated with overall oxidative stress.

Methods

We examined associations between single nucleotide polymorphisms SNPs in MnSOD, GSTP1, GSTM1, GPX1, GPX3, and CAT genes and thiobarbituric acid-reactive substances TBARS, a blood biomarker of oxidative damage, in healthy white women randomly selected from Western New York n = 1402. We used general linear models to calculate age-adjusted geometric means of TBARS across the variants. We also examined the associations within strata of menopausal status.

Results

For MnSOD, being heterozygous was associated with lower geometric means of TBARS less oxidative stress, 1.28 mg-dL, compared to homozygous T-allele or homozygous C-allele,1.35 mg-dL, and 1.31 mg-dL correspondingly p for trend = 0.01. This difference remained among postmenopausal women, 1.40 mg-dL for TT, 1.32 mg-dL for TC, and 1.34mg-dL for CC p for trend 0.015; it was attenuated among premenopausal women. SNPs in the other genes examined GSTP1, GSTM1, GPX1, GPX3, and CAT were not associated with TBARS.

Conclusions

Our findings suggest that genetic variation in MnSOD gene may be associated with oxidative status, particularly among postmenopausal women.



Author: Albina N. Minlikeeva , Richard W. Browne, Heather M. Ochs-Balcom, Catalin Marian, Peter G. Shields, Maurizio Trevisan, Shiva Kris

Source: http://plos.srce.hr/



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