Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian HormoneReport as inadecuate




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Objective

To explore the potential damaging effect of chronic pelvic inflammation on ovarian reserve.

Design

Case-control study.

Patients

A total of 122 women with bilateral tubal occlusion, diagnosed by hysterosalipingography HSG and 217 women with normal fallopians were recruited.

Measurements

Serum anti-Mullerian hormone AMH, basic follicle-stimulating hormone FSH, luteining hormone LH, estradiol E2, and testosterone T were measured; and antral follicle counts AFCs were recorded.

Results

Significantly lower level of AMH was observed in women with bilateral tubal occlusion compared to control group 2.62 2.95 ng-ml vs. 3.37 3.11 ng-ml, P = 0.03, and the difference remained after adjustment of BMI Padjust = 0.04. However, no statistical difference was found in the levels of FSH 7.00 2.16 IU-L vs. 6.74 2.30 IU-L, LH 4.18 1.52 IU-L vs. 4.63 2.52 IU-L, E2 35.95 20.40 pg-ml vs. 34.90 17.85 pg-ml, T 25.07±11.46 ng-dl vs. 24.84±12.75 ng-dl, and AFC 6.00 4.00 vs. 7.00 4.00 between two groups p>0.05.

Conclusions

Women with bilateral tubal occlusion showed decreased AMH level, suggesting that chronic pelvic inflammation may diminish ovarian reserve. More caution should be paid when evaluating the detriment of PID on female fertility.



Author: Linlin Cui, Yan Sheng, Mei Sun, Jingmei Hu, Yingying Qin , Zi-Jiang Chen

Source: http://plos.srce.hr/



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