Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-UpReport as inadecuate




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Background and Objective

The risk of developing multiple sclerosis MS as well as MS disease activity is associated with vitamin D 25OHD status. The relationship between the main functional disability hallmark of MS, disability progression, and 25OHD status is less well established though, especially not in MS patients with progressive disease.

Methods

This retrospective follow-up study included 554 MS patients with a serum baseline 25OHD level and Expanded Disability Status Scale EDSS with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25OHD status on relapse rate. Repeated measures linear regression analyses were performed to assess the effect on disability and disability progression.

Results

Baseline deseasonalized 25OHD status was associated with subsequent relapse risk yes-no, but only in the younger MS patients ≤ 37.5 years; OR = 0.872, per 10 nmol-L 25OHD, p = 0.041. Baseline 25OHD status was not significantly associated with either disability or disability progression, irrespective of MS phenotype.

Conclusion

Within the physiological range, 25OHD status is just significantly associated with the occurrence of relapses in younger MS patients, but is not associated with disability or disability progression over three years follow-up. Whether high dose supplementation to supra physiological 25OHD levels prevents disability progression in MS should become clear from long term follow-up of supplementation studies.



Author: Anne-Hilde Muris , Joost Smolders, Linda Rolf, Lieke J. J. Klinkenberg, Noreen van der Linden, Steven Meex, Jan Damoiseaux, Raymo

Source: http://plos.srce.hr/



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