Maternal Use of Selective Serotonin Reuptake Inhibitors and Lengthening of the Umbilical Cord: Indirect Evidence of Increased Foetal Activity—A Retrospective Cohort StudyReport as inadecuate




Maternal Use of Selective Serotonin Reuptake Inhibitors and Lengthening of the Umbilical Cord: Indirect Evidence of Increased Foetal Activity—A Retrospective Cohort Study - Download this document for free, or read online. Document in PDF available to download.

Background

Antenatal depression affects up to 19% of pregnant women. Some of these women are also in need of antidepressant treatment. Nevertheless, the impact of maternal antidepressant treatment and prenatal depression on the course of pregnancy, foetal development and delivery outcomes is not fully understood.

Methods

We analysed data from 24 818 women who gave birth at Kuopio University Hospital between 2002–2012. Logistic regression analysis was used to estimate associations between the use of selective serotonin reuptake inhibitors SSRIs during pregnancy and the progression of pregnancy, development of the foetus and delivery outcomes.

Results

Altogether, 369 1.5% women used SSRIs. A regression model adjusted for age, overweight, nulliparity, prior termination, miscarriages, smoking, maternal alcohol consumption, chronic illness and polyhydramnion showed that pregnant women exposed to SSRI medication had significantly lower Apgar scores at 1 minute p < 0.0001 and 5 minutes p < 0.0001 and more admissions to the neonatal intensive care unit p < 0.0001 than unexposed pregnant women. In addition, exposed newborns had longer umbilical cords p < 0.0001 than non-exposed newborns.

Conclusion

In addition to the previously known associates with maternal SSRI exposure, such as lowered Apgar scores, SSRI exposure appeared to be associated with increased umbilical cord length. The observation related to increased umbilical cord length may be explained by an SSRI-induced increase in the movements of the developing foetus.



Author: Julia Kivistö , Soili M. Lehto, Katja Halonen, Leena Georgiadis, Seppo Heinonen

Source: http://plos.srce.hr/



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