Cost-Effectiveness Analysis of Different Testing Strategies that Use Antibody Levels to Detect Chronic Hepatitis C in Blood DonorsReport as inadecuate




Cost-Effectiveness Analysis of Different Testing Strategies that Use Antibody Levels to Detect Chronic Hepatitis C in Blood Donors - Download this document for free, or read online. Document in PDF available to download.

Aim. We conducted a cost-effectiveness analysis of seven hepatitis C virus HCV testing strategies in blood donors. Methods. Three of the seven strategies were based on HCV diagnosis and reporting guidelines in Mexico and four were from previous and current recommendations outlined by the CDC. The strategies that were evaluated determine antibody levels according to the signal-to-cut-off S-CO ratio and use reflex Immunoblot IMB or HCV RNA tests to confirm true positive TP cases of chronic HCV infection. Costs were calculated from the perspective of the Mexican Institute of Social Security IMSS. A decision tree model was developed to estimate the expected number of true positive cases and costs for the base-case scenarios and for the sensitivity analyses. Results. Base-case findings indicate an extended dominance of the CDC-USA2 and CDC-USA4 options by the IMSS Mexico3 and IMSS-Mexico1 alternatives. The probabilistic sensitivity analyses results suggest that for a willingness-to-pay WTP range of $0–9,000 USD the IMSS-Mexico1 strategy is the most cost-effective of all strategies $5,000 USD per TP. The IMSS-Mexico3, IMSS-Mexico2, and CDC-USA3 strategies are also cost-effective strategies that cost between $7,800 and $8,800 USD per TP case detected. The CDC-USA1 strategy was very expensive and not cost-effective. Conclusions. HCV antibody testing strategies based on the classification of two or three levels of the S-CO are cost-effective procedures to identify patients who require reflex IMB or HCV RNA testing to confirm chronic HCV infection.



Author: Víctor Granados-García , Ana M. Contreras, Carmen García-Peña, Guillermo Salinas-Escudero, Hla-Hla Thein, Yvonne N. Flores

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents