Antidepressant Efficacy of Adjunctive Aerobic Activity and Associated Biomarkers in Major Depression: A 4-Week, Randomized, Single-Blind, Controlled Clinical TrialReport as inadecuate




Antidepressant Efficacy of Adjunctive Aerobic Activity and Associated Biomarkers in Major Depression: A 4-Week, Randomized, Single-Blind, Controlled Clinical Trial - Download this document for free, or read online. Document in PDF available to download.

Background

Major depressive disorder MDD is a highly prevalent, heterogeneous and systemic medical condition. Treatment options are limited, and recent studies have suggested that physical exercise can play an important role in the therapeutics of MDD. The aim of this study was to evaluate the antidepressant efficacy of adjunctive aerobic activity in association with pharmacotherapy selective serotonin reuptake inhibitor in symptomatic MDD as well as its association with physiological biomarkers.

Methods

In this randomized, single-blind, add-on, controlled clinical trial, 57 patients 18–55 years of age were followed-up for 28 days. All patients were drug-free, had been diagnosed with symptomatic MDD and received flexible dose of sertraline during the trial. Patients were randomized to either a 4-week program 4x-week of add-on aerobic exercise exercise group, N = 29 or no activity control group, N = 28. Depression severity was assessed using the Hamilton Rating Scale for Depression HAM-D as the primary outcome. At baseline and endpoint, all patients underwent a comprehensive metabolic-cardiopulmonary exercise testing—including determination of maximal oxygen uptake VO2max, VO2 at the second ventilatory threshold VO2-VT2, and oxygen pulse O2 pulse.

Results

Depression scores significantly decreased in both groups after intervention. Importantly, patients in the aerobic exercise group required lower sertraline dose compared to the control group sertraline monotherapy. The VO2max and O2 pulse parameters increased over time only in the exercise group and remained unchanged in the control group.

Conclusions

The present findings suggest that a 4-week training of aerobic exercise significantly improves functional capacity in patients with MDD and may be associated with antidepressant efficacy. This approach may also decrease the need for higher doses of antidepressants to achieve response. Further studies in unmedicated and treatment-resistant MDD patients are needed in order to confirm the utility of short-term aerobic exercise as an alternative therapeutic approach in MDD.

Trial Registration

ClinicalTrials.gov NCT02427789



Author: Cristiana Carvalho Siqueira, Leandro L. Valiengo, André F. Carvalho, Paulo Roberto Santos-Silva, Giovani Missio, Rafael T. de So

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents