Mathematical Based Calculation of Drug Penetration Depth in Solid TumorsReport as inadecuate




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BioMed Research International - Volume 2016 2016, Article ID 8437247, 8 pages -

Research Article

School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798

Department of Radiotherapy, Oncology and Palliative Care, Sarawak General Hospital, 93586 Kuching, Sarawak, Malaysia

Faculty of Cognitive Sciences and Human Development, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

Received 27 March 2016; Accepted 17 May 2016

Academic Editor: Osmar Nascimento Silva

Copyright © 2016 Hamidreza Namazi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cancer is a class of diseases characterized by out-of-control cells’ growth which affect cells and make them damaged. Many treatment options for cancer exist. Chemotherapy as an important treatment option is the use of drugs to treat cancer. The anticancer drug travels to the tumor and then diffuses in it through capillaries. The diffusion of drugs in the solid tumor is limited by penetration depth which is different in case of different drugs and cancers. The computation of this depth is important as it helps physicians to investigate about treatment of infected tissue. Although many efforts have been made on studying and measuring drug penetration depth, less works have been done on computing this length from a mathematical point of view. In this paper, first we propose phase lagging model for diffusion of drug in the tumor. Then, using this model on one side and considering the classic diffusion on the other side, we compute the drug penetration depth in the solid tumor. This computed value of drug penetration depth is corroborated by comparison with the values measured by experiments.





Author: Hamidreza Namazi, Vladimir V. Kulish, Albert Wong, and Sina Nazeri

Source: https://www.hindawi.com/



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