Overexpression and Biological Function of Ubiquitin-Specific Protease 42 in Gastric CancerReport as inadecuate




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Ubiquitin-specific protease 42 USP42 is a member of deubiquitinating enzymes DUBs. The alterations of DUBs are implicated in the pathogenesis of a wide variety of tumors. However, there are few studies on the expression and biological function of USP42 in gastric cancer GC. Here, the expression levels of USP42 were significantly higher in GC tissues than in non-tumorous tissues. USP42 expression was significantly correlated with tumor size, TNM stage, lymph node metastasis and overall survival of patients with GC. Moreover, USP42 silencing in two GC cell lines, AGS and MKN-45, notably inhibited cell proliferation, but stimulated G1 phase arrest. The proteins promoting cell cycle progression Cyclin D1, Cyclin E1 and PCNA were down-regulated in USP42-suppressed cells. Moreover, inhibition of USP42 in GC cells impaired cell invasion via affecting the expression of matrix metalloproteinases MMPs and epithelial-mesenchymal transition EMT regulators. In conclusion, USP42 overexpression could be a potential prognostic marker for GC, regulate the survival and invasive properties of GC, and may represent a novel therapeutic molecular target for this tumor.



Author: Kun Hou , Zhenya Zhu , Yong Wang, Chunhui Zhang, Shiyong Yu, Qi Zhu, Bo Yan

Source: http://plos.srce.hr/



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