Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIGReport as inadecuate




Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG - Download this document for free, or read online. Document in PDF available to download.

Case Reports in Hematology - Volume 2015 2015, Article ID 809313, 3 pages -

Case Report

Adult Blood and Marrow Transplant, Texas Transplant Institute, San Antonio, TX, USA

Sarah Cannon Blood Cancer Network, Nashville, TN 37203, USA

Cancer Care Centers of South Texas, 4411 Medical Drive, San Antonio, TX, USA

Texas Oncology, 901 W. 38th Street, Suite 200, Austin, TX 78705, USA

Received 29 December 2014; Revised 13 March 2015; Accepted 18 March 2015

Academic Editor: Kate Khair

Copyright © 2015 Behyar Zoghi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome AVWS undergoing autologous stem cell transplant ASCT are at significant risk of bleeding due to the profound thrombocytopenia, low Factor VIII levels, fever, and toxicities associated with the preparative regimen. We report a patient with AVWS associated with multiple myeloma who underwent autologous stem cell transplants as consolidation after initial induction and again at relapse. He was successfully treated with high dose intravenous immunoglobulin IVIG prior to each transplant with rapid resolution of AVWS.





Author: Behyar Zoghi, Paul Shaughnessy, Roger M. Lyons, Richard Helmer III, Carlos Bachier, and C. Frederick LeMaistre

Source: https://www.hindawi.com/



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