Reactions with N-1-benzotriazolylcarbonyl-amino acids. IV. The use of N-1-benzotriazolylcarbonyl-amino acid derivates in peptide synthesisReport as inadecuate




Reactions with N-1-benzotriazolylcarbonyl-amino acids. IV. The use of N-1-benzotriazolylcarbonyl-amino acid derivates in peptide synthesis - Download this document for free, or read online. Document in PDF available to download.

Croatica Chemica Acta, Vol.63 No.4 March 1991. -

The use of the 1-benzotriazolylearbonyl-Bte-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxyearbonyl-Z-group.

N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respcetively. This process is aceompanied with separation of benzotriazole and C02. Advantages and disadvantages of this method of peptide bond formation are discussed.



Author: B. Zorc - ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia G. Karlović - ; Faculty of Pharmacy

Source: http://hrcak.srce.hr/



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