Reproducibility of Heart Rate Variability Indices in Children with Cystic FibrosisReport as inadecuate




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Fundamental to the potential utilisation of heart rate variability HRV indices as a prognostic tool is the reproducibility of these measures. The purpose of the present study was therefore to investigate the reproducibility of 24-hour derived HRV indices in a clinical paediatric population. Eighteen children 10 boys; 12.4 ± 2.8 years with mild to moderate Cystic Fibrosis CF; FVC: 83 ± 12% predicted; FEV1: 80 ± 9% predicted and eighteen age- and sex-matched controls 10 boys; 12.5 ± 2.7 years wore a combined ECG and accelerometer for two consecutive days. Standard time and frequency domain indices of HRV were subsequently derived. Reproducibility was assessed by Bland-Altman plots, 95% limits of agreement and intra-class correlation coefficients ICC. In both groups, there was no systematic difference between days, with the variables demonstrating a symmetrical, homoscedastic distribution around the zero line. The time domain parameters demonstrated a good to excellent reproducibility irrespective of the population considered ICC: 0.56 to 0.86. In contrast, whilst the frequency domain parameters similarly showed excellent reproducibility in the healthy children ICC: 0.70 to 0.96, the majority of the frequency domain parameters illustrated a poor to moderate reproducibility in those with CF ICC: 0.22 to 0.43. The exceptions to this trend were the normalised LF and HF components which were associated with a good to excellent reproducibility. These findings thereby support the utilisation of time and relative frequency domain HRV indices as a prognostic tool in children with CF. Furthermore, the present results highlight the excellent reproducibility of HRV in healthy children, indicating that this may be a useful tool to assess intervention effectiveness in this population.



Author: Melitta A. McNarry , Kelly A. Mackintosh

Source: http://plos.srce.hr/



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