Syntheses of two deacetyl-thymosin β4 analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse pawReport as inadecuate




Syntheses of two deacetyl-thymosin β4 analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw - Download this document for free, or read online. Document in PDF available to download.

Mediators of Inflammation - Volume 10 2001, Issue 2, Pages 89-92

Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd., 2–546–1, Yoriki, Matsuomura, Iwate-gun, Iwate-ken, 028–7302, Japan



Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two {Met0

}deacetyl-thymosin β4 analogs containing Phe4F or TyrMe at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe

resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met0

}deacetyl-thymosin β4, but the other analog, {Met0

, TyrMe

}deacetyl-thymosin β4, showed a marked reduction of the anti-inflammatory effect.





Author: T. Abiko and R. Ogawa

Source: https://www.hindawi.com/



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