Breastfeeding and Immunohistochemical Expression of ki-67, p53 and BCL2 in Infiltrating Lobular Breast CarcinomaReport as inadecuate




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Background-Aim

Invasive lobular breast carcinoma is the second most common type of breast cancer after invasive ductal carcinoma. According to the American Cancer Society, more than 180,000 women in the United States find out they have invasive breast cancer each year. Personal history of breast cancer and certain changes in the breast are correlated with an increased breast cancer risk. The aim of this work was to analyze breastfeeding in patients with infiltrating lobular breast carcinoma, in relation with: 1 clinicopathological parameters, 2 hormonal receptors and 3 tissue-based tumor markers

Materials and Methods

The study included 80 women with ILC, 46 of which had breastfeed their children. Analyzed parameters were: age, tumor size, axillary lymph node N, distant metastasis M, histological grade HG, estrogen receptor ER, progesterone receptor PR, androgen receptor AR, Ki-67, p53 and BCL2

Results

ILC of non-lactating women showed a larger p = 0.009, lymph node involvement p = 0.051 and distant metastasis p = 0.060. They were also more proliferative tumors measured by Ki-67 p = 0.053. Breastfeeding history did not influence the subsequent behavior of the tumor regardless of histological subtype

Conclusion

Lactation seems to influence the biological characteristics of ILC defining a subgroup with more tumor size, axillary lymph node involvement, distant metastasis and higher proliferation measured by ki-67 expression.



Author: Angel Gonzalez-Sistal , Alicia Baltasar-Sánchez, Primitiva Menéndez, Jose Ignacio Arias, Álvaro Ruibal

Source: http://plos.srce.hr/



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