The TG-HDL-C Ratio Might Be a Surrogate for Insulin Resistance in Chinese Nonobese WomenReport as inadecuate

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International Journal of Endocrinology - Volume 2014 2014, Article ID 105168, 7 pages -

Research ArticleDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

Received 17 May 2014; Accepted 23 June 2014; Published 21 July 2014

Academic Editor: Giovannella Baggio

Copyright © 2014 Jiyun He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obejective. To examine the discriminatory power of triglyceride TG and triglyceride to high-density lipoprotein cholesterol ratio TG-HDL-C for insulin resistance IR in a normoglycaemic Chinese population. Methods. The data were collected from 711 individuals. The normoglycaemic individuals were eventually included in the study n = 533, age: 62.8 ± 6.6 years, male: 56.8%, who were with a fasting plasma glucose < 6.1 mmol-L and without a history of diabetes. IR was defined as the upper quintile ≥1.6 of homeostasis model assessment of IR. Area under the receiver operating characteristic curve AROC was used to examine the discriminatory power. Results. The discriminatory power of TG-HDL-C for IR was acceptable in women with a BMI < 24 kg-m

or waist circumference < 80 cm AROCs: 0.718 and 0.713, resp.; however, the discriminatory power was not acceptable in the obese women. TG-HDL-C was not an acceptable marker of IR in men. The discriminatory power of TG for IR was not acceptable in both men and women. Conclusions. The discriminatory power of TG-HDL-C for IR differs by gender and obesity index in the normoglycaemic Chinese population, and TG-HDL-C could discriminate IR in the nonobese and normoglycaemic women.

Author: Jiyun He, Sen He, Kai Liu, Yong Wang, Di Shi, and Xiaoping Chen



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