Role of -Sulesomab Immunoscintigraphy in the Management of Infection following Deep Brain Stimulation SurgeryReport as inadecuate




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Neurology Research InternationalVolume 2011 2011, Article ID 817951, 8 pages

Research Article

Department of Neurology, Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal

Faculty of Medicine, Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal

Department of Neurosurgery, Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal

Department of Nuclear Medicine, Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal

Received 3 March 2011; Revised 24 July 2011; Accepted 9 August 2011

Academic Editor: Changiz Geula

Copyright © 2011 Raquel Real et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Infection constitutes a serious adverse event in patients submitted to deep brain stimulation, often leading to removal of the device. We set to evaluate the potential role of immunoscintigraphy with -labelled antigranulocyte antibody fragments -sulesomab in the management of infection following DBS. -sulesomab immunoscintigraphy seems to correlate well with the presence and extent of infection, thus contributing to differentiate between patients who should remove the hardware entirely at presentation and those who could undergo a more conservative approach. Also, -sulesomab immunoscintigraphy has a role in determining the most appropriate timing for reimplantation. Finally, we propose an algorithm for the management of infection following DBS surgery, based on the results of the -sulesomab immunoscintigraphy.





Author: Raquel Real, Paulo Linhares, Hélder Fernandes, Maria José Rosas, Miguel F. Gago, Jorge Pereira, and Rui Vaz

Source: https://www.hindawi.com/



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