Integrating Cervical Cancer Screening with HIV Care in Cameroon: Comparative Risk Analysis of Cervical Disease in HIV-Infected Women Receiving Antiretroviral Therapy to Women in the General PopulationReport as inadecuate




Integrating Cervical Cancer Screening with HIV Care in Cameroon: Comparative Risk Analysis of Cervical Disease in HIV-Infected Women Receiving Antiretroviral Therapy to Women in the General Population - Download this document for free, or read online. Document in PDF available to download.

Background

While the effect of highly active antiretroviral therapy HAART on natural history of cervical lesions remains controversial, resource limited countries need to understand the relevance of their own data to their settings. We compared the risk of cervical disease in HAART-experienced women with that in women in the general population of Cameroon.

Methods

A retrospective cross sectional survey of women aged 35 years and above, attending a voluntary screening campaign for cervical cancer at the Nkongsamba Regional Hospital in Cameroon between February and May 2014. Squamous intraepithelial lesions SIL were determined by Pap smear. Multiple logistic regression was used to compare the odds of SIL in women on HAART to women from the community with unknown HIV status.

Results

Included were 302 women of whom 13143.4% were HIV-infected and receiving HAART on the site while 171 56.6% were women from the community. Cervical disease was observed in 5116.9% persons of whom 15 11.5% cases in the HAART group and 36 21.1% cases in the general group p = 0.027. After controlling for age and other covariates, women in the HAART group had a 67% reduction in the odds of cervical lesions compared with the community group adjusted odd ratio aOR = 0.33, 95%CI: 0.15–0.73, p = 0.006.

Conclusion

HIV-infected women receiving HAART have a lower risk of cancer than women in the general population. This finding may not be attributed to HAART alone but to all the health benefits derived from receiving a comprehensive HIV care.



Author: Cavin Epie Bekolo , Gillian O’Bryan, François Edmond Tchago, Charlette Nangue, Patrick Sylvestre Bekoule, Basile Kollo

Source: http://plos.srce.hr/



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