The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney DeficiencyReport as inadecuate

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Evidence-Based Complementary and Alternative Medicine - Volume 2012 2012, Article ID 102641, 8 pages -

Research Article

Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China

Preclinical College, Beijing University of Chinese Medicine, Beijing 100029, China

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700, China

China-Japan Friendship Hospital, Beijing 100029, China

Received 25 September 2011; Revised 28 November 2011; Accepted 9 December 2011

Academic Editor: Wei Jia

Copyright © 2012 Hongyan Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis RA. In traditional Chinese medicine TCM, the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state. In this study, TCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan Bi Pill YJB, was used to treat collagen induced arthritis CIA rats with castration. Metabolomic technique was used to evaluate the pharmacological mechanism in castrated CIA rats treated by YJB. The results showed that castration significantly increased the severity of the arthritis in rats but was ameliorated by YJB. Its pharmacological mechanism was partially associated with lipid metabolites involving free fatty acid FFA and lysophosphatidylcholine LPC. In conclusion, the experimental results demonstrate the protective effect of YJB on the TCM kidney deficiency pattern induced by androgen deficiency in CIA rats and support that YJB should be used for the clinical treatment of RA with TCM kidney deficiency pattern.

Author: Hongyan Zhao, Jian Li, Xiaojuan He, Cheng Lu, Cheng Xiao, Xuyan Niu, Ning Zhao, Dahong Ju, and Aiping Lu



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