Molecular Imaging of Cancer with Nanoparticle-Based Theranostic ProbesReport as inadecuate

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Contrast Media and Molecular Imaging - Volume 2017 2017, Article ID 1026270, 11 pages -

Review Article

Clinical Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou 310014, China

Key Laboratory of Cancer Molecular Diagnosis and Individualized Therapy of Zhejiang Province, Hangzhou 310014, China

Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, China

School of Basic Medical Sciences, Hangzhou Medical College, Hangzhou 310053, China

Correspondence should be addressed to Xiao-Zhou Mou

Received 31 March 2017; Accepted 16 May 2017; Published 19 June 2017

Academic Editor: Kai Yang

Copyright © 2017 Ying-Yu Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. However, current imaging contrasts and tracers, which are in widespread clinical use, have their intrinsic limitations and disadvantages. Nanotechnologies, which have improved in vivo detection and enhanced targeting efficiency for cancer, may overcome some of the limitations of cancer diagnosis and therapy. Theranostic nanoparticles have great potential as a therapeutic model, which possesses the ability of their nanoplatforms to load targeted molecule for both imaging and therapeutic functions. The resulting nanosystem will likely be critical with the growth of personalized medicine because of their diagnostic potential, effectiveness as a drug delivery vehicle, and ability to oversee patient response to therapy. In this review, we discuss the achievements of modern nanoparticles with the goal of accurate tumor imaging and effective treatment and discuss the future prospects.

Author: Ying-Yu Ma, Ke-Tao Jin, Shi-Bing Wang, Hui-Ju Wang, Xiang-Min Tong, Dong-Sheng Huang, and Xiao-Zhou Mou



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