Investigation of biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tabletsReport as inadecuate




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ADMET and DMPK, Vol.4 No.4 December 2016. -

The purpose of this study was to evaluate the biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tablets ODTs. The molecular weight MW, polar surface area PSA, hydrogen bond donor HBD and acceptor HBA numbers, net charge at pH 7.4, log D6.5, the highest dose strength, solubility in water, dose number, and elimination t1-2 of 57 ODT drugs and 113 drugs of immediate-release IR formulations were compared. These drugs were classified according to the Biopharmaceutical Classification System BCS. A lower dose strength and a longer elimination t1-2 have been observed as characteristic properties of ODTs. The proportion of basic drugs was higher in the ODTs than in the IR formulations. A significant difference was not observed between the ODT and the IR formulation for MW, PSA, HBD, HBA, log D6.5, solubility in water, and dose number. The distributions of the ODTs and IR formulations among each BCS class were similar, suggesting that an ODT can be developed regardless of the BCS class of a drug.

orally disintegrating tablet ODT; bioequivalence; biopharmaceutics classification system BCS



Author: Asami Ono - ; Asahi Kasei Pharma, 632-1 Mifuku, Izunokuni, Shizuoka 410-2321, Japan. Takumi Tomono - ; Laboratory of Clinical Pha

Source: http://hrcak.srce.hr/



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