Pattern of Drug Resistance and Risk Factors Associated with Development of Drug Resistant Mycobacterium tuberculosis in PakistanReport as inadecuate




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Background

Drug resistant tuberculosis DR-TB is a major public health problem in developing countries such as Pakistan.

Objective

The current study was conducted to assess the frequency of drug resistant tuberculosis including multi drug resistance MDR- TB as well as risk factors for development of DR-TB, in Punjab, Pakistan.

Methodology

Drug susceptibility testing DST was performed, using proportion method, for 2367 culture positive Mycobacterium tuberculosis MTB cases that were enrolled from January 2012 to December 2013 in the province of Punjab, Pakistan, against first-line anti-tuberculosis drugs. The data was analyzed using statistical software; SPSS version 18.

Results

Out of 2367 isolates, 273 11.5% were resistant to at least one anti-TB drug, while 221 9.3% showed MDR- TB. Risk factors for development of MDR-TB were early age ranges between 10–25 years and previously treated TB patients.

Conclusion

DR-TB is a considerable problem in Pakistan. Major risk factors are previous history of TB treatment and younger age group. It emphasizes the need for effective TB control Program in the country.



Author: Irfan Ullah , Arshad Javaid, Zarfishan Tahir, Obaid Ullah, Aamer Ali Shah, Fariha Hasan, Najma Ayub

Source: http://plos.srce.hr/



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