A Rapid Replacement of Vimentin-Containing Radial Glia by Glial Fibrillary Acidic Protein-Containing Astrocytes in Transplanted TelencephalonReport as inadecuate




A Rapid Replacement of Vimentin-Containing Radial Glia by Glial Fibrillary Acidic Protein-Containing Astrocytes in Transplanted Telencephalon - Download this document for free, or read online. Document in PDF available to download.

Journal of Neural Transplantation and Plasticity - Volume 6 1997, Issue 1, Pages 21-29

Department of Anatomy, Histology, and Embryology, Semmelweis University of Medicine, Tüzoltó 58, Budapest H-1450, Hungary



Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study follows the early events in the development of astroglia in rat embryonic El5 tissue grafted into the cortex of adult rats. Astroglial elements radial glia and astrocytes were studied by glial fibrillary acidic protein GFAP and vimentin immunohistochemistry on post-transplantation PT days 7, 11, 14, 17, and 21. At PT7, GFAP-immunopositive elementswere only scarce fibers in the transplants. At PTll, a dense network of long, GFAP-immunopositive fibers enmeshed the entiretransplant, and astrocytes were already recognized. The fibers also showed vimentin immunoreactivity. By PT14, astrocytes became the predominant GFAP-labeled elements, although a few long fibers persisted. When compared with in situ development, the graftsshowed earlier GFAP-immunoreactivity and earlier appearance of astrocytes, as well as a more rapid transition from the immature to themature form of the glial system.





Author: Andrea Tuba, Lázló Kállai, and Mihály Kálmán

Source: https://www.hindawi.com/



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