Garlic Attenuates Plasma and Kidney ACE-1 and AngII Modulations in Early Streptozotocin-Induced Diabetic Rats: Renal Clearance and Blood Pressure ImplicationsReport as inadecuate




Garlic Attenuates Plasma and Kidney ACE-1 and AngII Modulations in Early Streptozotocin-Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications - Download this document for free, or read online. Document in PDF available to download.

Evidence-Based Complementary and Alternative Medicine - Volume 2016 2016, Article ID 8142394, 11 pages -

Research ArticleDepartment of Biological Sciences, Faculty of Science, Kuwait University, P.O. Box 5969, 13060 Safat, Kuwait

Received 21 March 2016; Accepted 24 April 2016

Academic Editor: Khalid Rahman

Copyright © 2016 Khaled K. Al-Qattan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Raw garlic aqueous extract GE has ameliorative actions on the renin-angiotensin system in type-1 diabetes mellitus DM; however its effects on plasma and kidney angiotensin I converting enzyme type-1 ACE-1 and angiotensin II AngII require further elucidation. This study investigated the effect of GE on plasma and kidney ACE-1 and AngII concentrations and in relation to systemic and renal clearance indicators significant to blood pressure BP homeostasis in early streptozotocin- STZ- induced type-1 DM. Normal rats received 0.5 mL normal saline NR-NS, diabetic rats received 0.5 mL NS DR-NS, and treated diabetic rats received 50 mg-0.1 mL-100 g body weight GE DR-GE as daily intraperitoneal injections for 8 weeks. Compared to NR-NS, DR-NS showed a significant increase in plasma ACE-1 and AngII and conversely a decrease in kidney ACE-1 and AngII. These changes were associated with an increase in BP and clearance functions. Alternatively and compared to DR-NS, DR-GE showed normalization or attenuation in plasma and kidney ACE-1 and AngII. These GE induced rectifications were associated with moderation in BP elevation and renal clearance functions. Garlic attenuates modulations in plasma and kidney ACE-1 and AngII, in addition to BP and renal clearance function in type-1 DM.





Author: Khaled K. Al-Qattan, Martha Thomson, Divya Jayasree, and Muslim Ali

Source: https://www.hindawi.com/



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