Elevated Progesterone Levels on the Day of Oocyte Maturation May Affect Top Quality Embryo IVF CyclesReport as inadecuate




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In contrast to the impact of elevated progesterone on endometrial receptivity, the data on whether increased progesterone levels affects the quality of embryos is still limited. This study retrospectively enrolled 4,236 fresh in vitro fertilization IVF cycles and sought to determine whether increased progesterone is associated with adverse outcomes with regard to top quality embryos TQE. The results showed that the TQE rate significantly correlated with progesterone levels on the day of human chorionic gonadotropin hCG trigger P = 0.009. Multivariate linear regression analysis of factors related to the TQE rate, in conventional IVF cycles, showed that the TQE rate was negatively associated with progesterone concentration on the day of hCG OR was -1.658, 95% CI: -2.806 to -0.510, P = 0.005. When the serum progesterone level was within the interval 2.0–2.5 ng-ml, the TQE rate was significantly lower P <0.05 than when the progesterone level was < 1.0 ng-ml; similar results were obtained for serum progesterone levels >2.5 ng-ml. Then, we choose a progesterone level at 1.5ng-ml, 2.0 ng-ml and 2.5 ng-ml as cut-off points to verify this result. We found that the TQE rate was significantly different P <0.05 between serum progesterone levels < 2.0 ng-ml and >2.0 ng-ml. In conclusion, the results of this study clearly demonstrated a negative effect of elevated progesterone levels on the day of hCG trigger, on TQE rate, regardless of the basal FSH, the total gonadotropin, the age of the woman, or the time of ovarian stimulation. These data demonstrate that elevated progesterone levels >2.0 ng-ml before oocyte maturation were consistently detrimental to the oocyte.



Author: Bo Huang, Xinling Ren, Li Wu, Lixia Zhu, Bei Xu, Yufeng Li, Jihui Ai, Lei Jin

Source: http://plos.srce.hr/



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