Toxic effects of two carbamate insecticides in dogsReport as inadecuate

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Archives of Industrial Hygiene and Toxicology, Vol.24 No.3 December 1973. -

In workers exposed to propoxur 2-isopropoxyphenyl methylcarbamate and promecarb 3-methyl-5-isopropylphenyl methyl carbamate the duration of plasma cholinesterase inhibition significantly differs. The aim of the present work was to find out whether this is due to differences related to enzyme-inhibitor interaction or to differences in insecticide absorption. Approximate equitoxic doses of the two carbamates were injected to dogs intravenously and intramuscularly. The intensity and quality of cholinergic symptoms were recorded and plasma cholinesterase activity measured at given time intervals. While the differences were found only after intramuscular application, the enzyme activity recovery was similar for both carbamates injected intravenously. The delayed plasma cholinesterase recovery in the case of promecarb could be explained by a much slower absorption after intramuscular injection of the compound.




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