Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese MenReport as inadecuate




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Context

Glucose and lipids stimulate the gut-hormones glucagon-like peptide GLP-1, GLP-2 and glucose-dependent insulinotropic polypeptide GIP but the effect of these on human postprandial lipid metabolism is not fully clarified.

Objective

To explore the responses of GLP-1, GLP-2 and GIP after a fat-rich meal compared to the same responses after an oral glucose tolerance test OGTT and to investigate possible relationships between incretin response and triglyceride-rich lipoprotein TRL response to a fat-rich meal.

Design

Glucose, insulin, GLP-1, GLP-2 and GIP were measured after an OGTT and after a fat-rich meal in 65 healthy obese BMI 26.5–40.2 kg-m2 male subjects. Triglycerides TG, apoB48 and apoB100 in TG-rich lipoproteins chylomicrons, VLDL1 and VLDL2 were measured after the fat-rich meal.

Main Outcome Measures

Postprandial responses area under the curve, AUC for glucose, insulin, GLP-1, GLP-2, GIP in plasma, and TG, apoB48 and apoB100 in plasma and TG-rich lipoproteins.

Results

The GLP-1, GLP-2 and GIP responses after the fat-rich meal and after the OGTT correlated strongly r = 0.73, p<0.0001; r = 0.46, p<0.001 and r = 0.69, p<0.001, respectively. Glucose and insulin AUCs were lower, but the AUCs for GLP-1, GLP-2 and GIP were significantly higher after the fat-rich meal than after the OGTT. The peak value for all hormones appeared at 120 minutes after the fat-rich meal, compared to 30 minutes after the OGTT. After the fat-rich meal, the AUCs for GLP-1, GLP-2 and GIP correlated significantly with plasma TG- and apoB48 AUCs but the contribution was very modest.

Conclusions

In obese males, GLP-1, GLP-2 and GIP responses to a fat-rich meal are greater than following an OGTT. However, the most important explanatory variable for postprandial TG excursion was fasting triglycerides. The contribution of endogenous GLP-1, GLP-2 and GIP to explaining the variance in postprandial TG excursion was minor.



Author: Niina Matikainen, Elias Björnson, Sanni Söderlund, Christofer Borén, Björn Eliasson, Kirsi H. Pietiläinen, Leonie H. Bogl, A

Source: http://plos.srce.hr/



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