Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland TumorReport as inadecuate




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Background

Upregulation of heparanase has been reported in an increasing number of human cancer tissues. However, the level of salivary heparanase and its clinical significance in patients with salivary gland tumors remain unclear.

Methods

Salivary heparanase levels in patients with salivary gland tumors were detected using enzyme-linked immunosorbent assays ELISAs and the clinical significance was evaluated by analyzing the correlations among salivary heparanase levels, clinicopathological parameters, and clinical outcomes.

Results

The levels of salivary heparanase were significantly higher in patients with malignant salivary gland tumors than in benign tumors and normal controls P<0.0001. High salivary heparanase levels were positively correlated with increased lymph node metastasis P = 0.0235 and poorer tumor node metastasis stage TNM P = 0.0183. Survival analyses revealed that high salivary heparanase levels were associated with worse overall survival P = 0.0023 and disease-free survival DFS P = 0.0025.

Conclusions

The study shows that salivary heparanase levels, as detected by the ELISAs, can be used to diagnose and provide an accurate prognosis for malignant salivary gland tumors. Salivary heparanase level was an independent predictor in patients with malignant salivary gland tumors.



Author: Xiangbing Wu , Jun Yu , Guilin Gao , Xin Wang, Yang Liu, Shengrong Zhu, Zhongjian Gong

Source: http://plos.srce.hr/



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