Feasibility of Elective Nodal Irradiation ENI and Involved Field Irradiation IFI in Radiotherapy for the Elderly Patients Aged ≥ 70 Years with Esophageal Squamous Cell Cancer: A Retrospective Analysis from a Single InstituteReport as inadecuate




Feasibility of Elective Nodal Irradiation ENI and Involved Field Irradiation IFI in Radiotherapy for the Elderly Patients Aged ≥ 70 Years with Esophageal Squamous Cell Cancer: A Retrospective Analysis from a Single Institute - Download this document for free, or read online. Document in PDF available to download.

Purpose

We conducted a retrospective analysis to assess the feasibility of involved field irradiation IFI in elderly patients with esophageal squamous cell cancer ESCC.

Materials and Methods

We performed a retrospective review of the records of elderly patients ≥ 70 years with unresectable ESCC and no distant metastases who received treatment with radiotherapy between January 2009 and March 2013. According to the irradiation volume, patients were allocated into either the elective nodal irradiation ENI group or the IFI group. Overall survival OS, progression-free survival PFS and treatment-related toxicities were compared between the two groups.

Results

A total of 137 patients were enrolled. Fifty-four patients 39.4% were allocated to the ENI group and 83 patients 60.6% to the IFI group, the median doses in the two groups were 60 Gy and 59.4 Gy, respectively. For the entire group, the median survival time MST and PFS were 16 months and 12 months, respectively. The median PFS and 3-year PFS rate in the ENI group were 13 months and 20.6%, compared to 11 months and 21.0% in the IFI groups p = 0.61. The MST and 3-year OS rate in the ENI and IFI groups were 17 months and 26.4% and 15.5 months and 21.7%, respectively p = 0.25. The rate of grade ≥ 3 acute irradiation esophagitis in the ENI group was significantly higher than that in the IFI group 18.5% vs. 6.0%; p = 0.027. Other grade ≥ 3 treatment-related toxicities did not significantly differ between the two groups.

Conclusions

IFI resulted in decreased irradiation toxicities without sacrificing OS in elderly patients with ESCC.



Author: Wang Jing , Hui Zhu , Hongbo Guo, Yan Zhang, Fang Shi, Anqin Han, Minghuan Li, Li Kong , Jinming Yu

Source: http://plos.srce.hr/



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