Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water to the Protection against Metabolic Syndrome Induction in Fructose-Fed Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox ApproachReport as inadecuate




Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water to the Protection against Metabolic Syndrome Induction in Fructose-Fed Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox Approach - Download this document for free, or read online. Document in PDF available to download.

International Journal of Endocrinology - Volume 2014 2014, Article ID 384583, 17 pages -

Research Article

Department of Biochemistry U38-FCT, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

Department of Clinical Pathology, São João Hospital Centre, EPE, 4200-319 Porto, Portugal

Faculty of Nutrition and Food Sciences, University of Porto, 4200-465 Porto, Portugal

QOPNA, Mass Spectrometry Centre, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal

CIAFEL, Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, 4200-450 Porto, Portugal

Received 5 September 2013; Revised 24 November 2013; Accepted 28 November 2013; Published 5 February 2014

Academic Editor: Amelie Bonnefond

Copyright © 2014 Cidália Dionísio Pereira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Metabolic Syndrome increases the risk for atherosclerotic cardiovascular disease and type 2 Diabetes Mellitus. Increased fructose consumption and-or mineral deficiency have been associated with Metabolic Syndrome development. This study aimed to investigate the effects of 8 weeks consumption of a hypersaline sodium-rich naturally sparkling mineral water on 10% fructose-fed Sprague-Dawley rats Metabolic Syndrome animal model. The ingestion of the mineral water rich in sodium bicarbonate and with higher potassium, calcium, and magnesium content than the tap water used as control reduced-prevented not only the fructose-induced increase of heart rate, plasma triacylglycerols, insulin and leptin levels, hepatic catalase activity, and organ weight to body weight ratios for liver and both kidneys but also the decrease of hepatic glutathione peroxidase activity and oxidized glutathione content. This mineral-rich water seems to have potential to prevent Metabolic Syndrome induction by fructose. We hypothesize that its regular intake in the context of modern diets, which have a general acidic character interfering with mineral homeostasis and are poor in micronutrients, namely potassium, calcium, and magnesium, could add surplus value and attenuate imbalances, thus contributing to metabolic and redox health and, consequently, decreasing the risk for atherosclerotic cardiovascular disease.





Author: Cidália Dionísio Pereira, Milton Severo, João Ricardo Araújo, João Tiago Guimarães, Diogo Pestana, Alejandro Santos, R

Source: https://www.hindawi.com/



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