Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African AmericansReport as inadecuate




Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans - Download this document for free, or read online. Document in PDF available to download.

Background

African Americans suffer from disproportionately high rates of hypertension and cardiovascular disease. Psychosocial stress, lifestyle and telomere dysfunction contribute to the pathogenesis of hypertension and cardiovascular disease. This study evaluated effects of stress reduction and lifestyle modification on blood pressure, telomerase gene expression and lifestyle factors in African Americans.

Methods

Forty-eight African American men and women with stage I hypertension who participated in a larger randomized controlled trial volunteered for this substudy. These subjects participated in either stress reduction with the Transcendental Meditation technique and a basic health education course SR or an extensive health education program EHE for 16 weeks. Primary outcomes were telomerase gene expression hTERT and hTR and clinic blood pressure. Secondary outcomes included lifestyle-related factors. Data were analyzed for within-group and between-group changes.

Results

Both groups showed increases in the two measures of telomerase gene expression, hTR mRNA levels SR: p< 0.001; EHE: p< 0.001 and hTERT mRNA levels SR: p = 0.055; EHE: p< 0.002. However, no statistically significant between-group changes were observed. Both groups showed reductions in systolic BP. Adjusted changes were SR = -5.7 mm Hg, p< 0.01; EHE = -9.0 mm Hg, p < 0.001 with no statistically significant difference between group difference. There was a significant reduction in diastolic BP in the EHE group -5.3 mm Hg, p< 0.001 but not in SR -1.2 mm Hg, p = 0.42; the between-group difference was significant p = 0.04. The EHE group showed a greater number of changes in lifestyle behaviors.

Conclusion

In this pilot trial, both stress reduction Transcendental Meditation technique plus health education and extensive health education groups demonstrated increased telomerase gene expression and reduced BP. The association between increased telomerase gene expression and reduced BP observed in this high-risk population suggest hypotheses that telomerase gene expression may either be a biomarker for reduced BP or a mechanism by which stress reduction and lifestyle modification reduces BP.

Trial Registration

ClinicalTrials.gov NCT00681200



Author: Shanthi Duraimani, Robert H. Schneider, Otelio S. Randall, Sanford I. Nidich, Shichen Xu, Muluemebet Ketete, Maxwell A. Rainforth

Source: http://plos.srce.hr/



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