Numerical Simulations of Effects of Multiple Neurotransmission on Intestinal Propulsion of a Non-Deformable BolusReport as inadecuate

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Computational and Mathematical Methods in Medicine - Volume 8 2007, Issue 1, Pages 11-36

Original Article

I-BIO Program, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea

Kazan Medical University, Tatarstan, Russia

Received 4 April 2006; Revised 31 October 2006; Accepted 15 December 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Electrophysiological mechanisms of co-transmission by serotonin 5-HT and acetylcholine ACh, co-expression of receptor types 5-HT type 3 and 4, nicotinic cholinerginc nACh and muscarinic cholinergic μACh, and effects of selective and non-selective 5-HT3 and 5-HT4 receptor agonists-antagonists, on intestinal propulsion of a solid non-deformable bolus were studied numerically. Results indicated that the propagation of the wave of excitation in the presence of 5-HT3 receptor antagonists was supported by co-release of ACh. Co-stimulation of 5-HT3, nACh and μACh receptors significantly impairs propulsive activity of the gut. In an ACh-free environment, Lotronex increased the transit time of the bolus along a segment of the gut. In the presence of ACh, Lotronex produced intensive tonic-type contractions in the longitudinal and circular smooth muscle layers and eliminated propulsive activity. Zelnorm preserved the reciprocal electromechanical relationships between the longitudinal and circular smooth muscle layers. The drug changed the normal mixing pattern of activity to an expulsive type. Treatment of the gut with selective 5HT4 receptor antagonists increased the transit time by disrupting the migrating myoelectrical complex. Cisapride increased the excitability of the myenteric nervous plexus and increased the frequency of slow waves. In the presence of Cisapride smooth muscle syncytia responded with the generation of tonic contractions, resulting in a -squeezing- type of bolus movement. Comparison of the theoretical results to in vivo and in vitro experimental data indicated satisfactory qualitative and quantitative agreement.

Author: R. Miftahof and N. Akhmadeev



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