High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control StudyReport as inadecuate




High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study - Download this document for free, or read online. Document in PDF available to download.

Journal of Immunology Research - Volume 2017 2017, Article ID 3972706, 8 pages - https:-doi.org-10.1155-2017-3972706

Research ArticleDepartment of Dermatology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey

Correspondence should be addressed to Ozlem Ozbagcivan

Received 23 September 2016; Accepted 7 December 2016; Published 3 January 2017

Academic Editor: Margarete D. Bagatini

Copyright © 2017 Sevgi Akarsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although it is known that systemic form of lupus erythematosus LE and metabolic syndrome MetS are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE DLE with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. This was a cross-sectional, case-control study, including 60 patients with DLE and 82 age- and gender-matched control subjects. In DLE group, the presence of MetS was observed as more frequent 48.3% versus 24.4%, , and hypertriglyceridemia 43.3% versus 22.0%, and reduced HDL-cholesterol 61.7% versus 23.2%, among the MetS components were found significantly higher when compared to the control group. DLE patients with MetS were at older age versus , , and hypertension, hyperlipidemia-dyslipidemia, and cardiovascular disease histories were observed at a higher ratio when compared to the patients without MetS. Between the DLE patients with and without MetS, no significant difference was observed in terms of clinical characteristics of DLE. Moreover, further large case-control studies with follow-up periods would be required to clearly assess the impact of MetS on the clinical outcomes of DLE.





Author: Sevgi Akarsu, Ozlem Ozbagcivan, Fatma Semiz, and Sebnem Aktan

Source: https://www.hindawi.com/



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